Timothy 'Tim' Hughes, M.D.: An ENT doctor husband of Heather (Short) Hughes father of Tyler, Samantha, and Sophia Hughes. She gives birth to their second daughter in 'Lost Math Art Glam'. She told her husband that she is pregnant again in 'Video Piercing Model Hangover'. She announced that she is pregnant with their second child in season 1 finale, 'Crytunes Divorce Tablet Ring' however, it was later revealed that she had a miscarriage in the season 2 premiere, 'Annulled Roommate Pill Shower'.

Zoe Lister-Jones as Jennifer 'Jen' Collins Short: A lawyer mother of Lark and Talia Short wife of Greg Short.

They adopt Lucas, an orphan boy, before season 4 episode 6. They get married at the end of season 2, 'Poison Fire Teats Universe'. They become engaged in the second half of the two-part season 1 finale, 'Crytunes Divorce Tablet Ring'. He and Colleen get back together in 'Cinderella Fantasy Prom Dougie'.

Thomas Sadoski as Matthew 'Matt' Short: Divorced shortly before season 1 began (wife was Bonnie) middle child and oldest son of John and Joan Short brother of Heather and Greg Short dates Colleen Brandon Ortega until the end of 'Hair Recital Rainbow Mom'.

Tim Hughes oldest child and only daughter of John and Joan Short older sister of Matt and Greg Short mother of Tyler, Samantha, and Sophia Hughes a stay at home mom. Betsy Brandt as Heather (Short) Hughes: Wife of Dr.He ends up running a small company by accident in 'Graffiti Cute Jewelry Shots'. Colin Hanks as Gregory 'Greg' Short: Husband of Jen Short youngest child of John and Joan Short younger brother of Matt Short and Heather (Short) Hughes father of Lark and Talia Short worked for a crowd funding website until he quit his job in 'Crytunes Divorce Tablet Ring'.

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